Residents (Steven Pasquale, Reiko Aylesworth, John Ortiz) of Gunnison, Colorado, are caught up in the crossfire when two deadly extraterrestrial species bring their longstanding conflict to Earth. On the one side, nearly indestructible Aliens; on the other, a lone Predator whose mission is to wipe out all traces of the Alien infestation from Earth, no matter who gets in the way.
No one can escape from the aggressive predatory Xenomorphs, and shortly after the Antarctic bloodshed in Alien Vs Predator (2004), a crippled Predator ship crash-lands on the dense forest of Gunnison, Colorado. As a result, a vicious Predalien hybrid, along with numerous Stage 1 Xenomorphs, or Face-huggers, scatter in all directions, infecting everyone unfortunate enough to cross their path. Once more, the Earth is a battlefield, as both extraterrestrial species are fighting for supremacy, and the humans become stuck in the middle. Now, the fate of the entire city rests in the hands of Sheriff Eddie Morales, and a handful of residents. Can they ensure the fate of humankind?