Seductive vampire Selene (Kate Beckinsale) and renegade werewolf Michael (Scott Speedman) love one another, but find themselves abhorred by the members of their own clans. Seeking clues that might provide a key to healing the rift between their species, they are hounded by Marcus (Tony Curran), an ancient creature obsessed with perpetuating the war between them. Continually beset by enemies from both sides, the lovers explore their pasts as they seek their destin
As the war between the vampires and the Lycans rages on, the beautiful vampire, Selene, a former member of the Death Dealers, and Michael, the werewolf hybrid, work together in an effort to unlock the secrets of their respective bloodlines. In this ancient feud between the two tribes, they try to unlock the secrets, in a modern tale of action, intrigue, and forbidden love, which takes them into the battle to end all wars, as the immortals must finally face their doom.